New research reveals that patients who stop using new GLP-1 drugs like Wegovy and Mounjaro can put back on lost weight far faster than those who stop conventional diet and exercise plans.
Research printed in a prominent health publication points out that while overweight individuals can lose a large proportion of their total mass while on the medication, the weight comes back at an average rate of 0.8 kg per month upon discontinuation.
"Individuals purchasing such treatments must be cognizant of the risk of rapid rebound weight gain when the medication is stopped," warns expert Dr. Susan Jebb.
This pace of regain implies a return to starting weight in about 18 months.
Analyzing Treatments
The study, which reviewed dozens of studies involving over 9,000 of patients, compared the outcomes of the injectable medications with other pills.
Scientists note that individuals who lose weight through lifestyle changes alone generally experience a slower weight regain—approximately 0.1 kg a month—once they finish.
The Reason for the Quick Regain
Doctors believe the mechanism of the drugs accounts for the accelerated weight return.
These medications copy a body's own chemical called GLP-1, which controls hunger.
"Long-term administration of GLP-1 levels several times higher than the body's typical production may cause the body to generate a reduced amount of its endogenous hormone, and may also diminish responsiveness to its effects," said Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this hormone supplement leads to appetite is no longer kept in check, making binge eating a significant risk."
A Chronic Issue?
Health authorities suggest the jabs for individuals with weight-linked health risks, alongside prescribed lifestyle changes.
A number of clinicians say that, due to the likelihood of relapse, the therapy is often ongoing.
This view is reinforced by pharmaceutical companies, who note that the results "emphasize the chronic character of obesity," comparing it to managing diseases like hypertension.
Patient Accounts
Users who have stopped the jabs describe a sudden resurgence of cravings.
"It felt as if a switch flipping and you become starving," recalled a patient.
This challenge is exacerbated if patients have not established lasting dietary or behavioural changes during therapy.
Significant Use
Recent estimates show that a significant number of adults in the UK have used these injections in the past year, with interest being substantial.
- Adoption is greater among women compared to males.
- The middle-aged age group shows the highest usage rates.
- Many access the drugs through private healthcare rather than the NHS.
Finally, clinicians caution that while these medications are effective agents for weight loss, they are not a magic solution and lasting health benefits likely depends on combined behavioural changes.
